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Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients, by Ben Goldacre
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"Smart, funny, clear, unflinching: Ben Goldacre is my hero." ―Mary Roach, author of Stiff, Spook, and Bonk
We like to imagine that medicine is based on evidence and the results of fair testing and clinical trials. In reality, those tests and trials are often profoundly flawed. We like to imagine that doctors who write prescriptions for everything from antidepressants to cancer drugs to heart medication are familiar with the research literature about these drugs, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by the pharmaceutical industry. We like to imagine that regulators have some code of ethics and let only effective drugs onto the market, when in reality they approve useless drugs, with data on side effects casually withheld from doctors and patients.
All these problems have been shielded from public scrutiny because they are too complex to capture in a sound bite. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct in the medical industry affects us on a global scale.
With Goldacre's characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system in need of regulation. This is the pharmaceutical industry as it has never been seen before.
- Sales Rank: #47920 in Books
- Brand: Goldacre, Ben
- Published on: 2014-04-01
- Released on: 2014-04-01
- Original language: English
- Number of items: 1
- Dimensions: 8.23" h x 1.27" w x 5.48" l, .92 pounds
- Binding: Paperback
- 480 pages
From Booklist
In the follow-up to his popular Bad Science (2010), British medical doctor Goldacre reveals how pharmaceutical companies mislead doctors and hurt patients. They “sponsor” trials, which tend to yield favorable results, while negative results often remain unreported. He also reports that drug companies spend twice as much on marketing and advertising as on researching and developing new drugs. Unfortunately for U.S. readers, he focuses largely on the UK, but ghost authorship of studies and “continuing medical education” boondoggle trips for doctors are problematic everywhere, and he does refer to the U.S. Food and Drug Administration on multiple occasions. And everyone, everywhere should feel unsettled by his discovery that pharmaceutical companies funnel $10 million to $20 million a year to such major medical journals as the New England Journal of Medicine and the Journal of the American Medical Association. Not surprisingly, he notes, studies funded by the pharmaceutical industry are that much more likely to get published in these influential journals. Goldacre’s essential exposé will prompt readers to ask more questions before automatically popping a doctor-prescribed pill. --Karen Springen
From Bookforum
Bad Pharma is surely the most comprehensive account to date of how the pharmaceutical industry games the regulatory process. Still, Bad Pharma is short on practical prescriptions for reform, and it is not until the last ten pages that Goldacre acknowledges that drug companies are manufacturing products that save lives and alleviate pain for billions of people. —Chris Wilson
Review
“Slightly technical, eminently readable, consistently shocking, occasionally hectoring and unapologetically polemical . . . This is a book that deserves to be widely read, because anyone who does read it cannot help feeling both uncomfortable and angry.” ―The Economist
“Ben Goldacre has done it again . . . This is a morbidly fascinating and dispiriting account, yet one which deserves (and needs) to be read and acted upon without delay.” ―Dennis Rosen, Dennis Rosen, The Boston Globe
“Read this book. It will make you mad, it will make you scared. And, hopefully, it will bring about some change. ” ―Chris Lee, Ars Technica
“A thorough piece of investigative medical journalism. What keeps you turning its pages is the accessibility of Goldacre's writing, . . . his genuine, indignant passion, his careful gathering of evidence and his use of stories, some of them personal, which bring the book to life.” ―Luisa Dillner, The Guardian
“Goldacre's research is scrupulous, and lay readers may find themselves converted by his geeky ardor. ” ―The New Yorker
“[A]n eye-opening glance into a world of experts who have failed us.” ―The New York Times Book Review
“In this searing exposé of the pharmaceutical industry, physician and journalist Goldacre uncovers a cesspool of corrupt practices designed to sell useless or dangerous drugs to an unsuspecting public . . . Goldacre conveys complicated scientific, medical, and ethical issues in simple, clear, plainspoken language that pulls no punches. The result is a smart, infuriating diagnosis of the rotten heart of the medical-industrial complex.” ―Publishers Weekly
“A useful guide for policymakers, doctors and the patients who need protection against deliberate disinformation.” ―Kirkus Reviews
“Goldacre's essential exposé will prompt readers to ask more questions before automatically popping a doctor-prescribed pill.” ―Karen Springen, Booklist
“Smart, funny, clear, unflinching: Ben Goldacre is my hero.” ―Mary Roach, author of Stiff, Spook, and Bonk, on Bad Science
“Ben Goldacre is exasperated . . . He is irked, vexed, bugged, ticked off at sometimes inadvertent (because of stupidity) but more often deliberate deceptions perpetrated in the name of science . . . You'll get a good grounding in the importance of evidence-based medicine . . . ‘Studies show' is not good enough, he writes: ‘The plural of "anecdote" is not data.'” ―Katherine Bouton, The New York Times, on Bad Science
“One of the best books I've ever read. It completely changed the way I saw the world. And I actually mean it. ” ―Tim Harford, author of The Undercover Economist, on Bad Science
“Ben Goldacre lucidly, and irreverently, debunks a frightening amount of pseudoscience, from cosmetics to dietary supplements to alternative medicine. If you want to read one book to become a better-informed consumer and citizen, read Bad Science.” ―Sandeep Jauhar, author of Intern, on Bad Science
“This is a much-needed book. Ben Goldacre shows us--with hysterical wit--how to separate the scam artists from real science. In a world of misinformation, this is a rare gem.” ―Timothy Ferriss, author of The 4-Hour Workweek, on Bad Science
“Ben Goldacre uses a brilliant mix of science and wit to challenge and investigate alternative therapists and the big pharmaceutical corporations. Bad Science is an invaluable tool for anybody who wants to protect themselves from the snake-oil salesmen of the twenty-first century.” ―Simon Singh, author of Big Bang and Fermat's Last Theorem, on Bad Science
“British physician and journalist Ben Goldacre takes aim at quack doctors, pharmaceutical companies and poorly designed studies in extraordinary fashion in Bad Science . . . Goldacre shines in a chapter about bad scientific studies by writing it from the perspective of a make-believe big pharma researcher who needs to bring a mediocre new drug to market. He explains exactly how to skew the data to show a positive result. 'I'm so good at this I scare myself,' he writes. 'Comes from reading too many rubbish trials.'” ―Rachel Saslow, The Washington Post, on Bad Science
“Funny and biting . . . While it is a very entertaining book, it also provides important insight into the horrifying outcomes that can result when willful anti-intellectualism is allowed equal footing with scientific methodology.” ―Dennis Rosen, The Boston Globe, on Bad Science
“I hereby make the heretical argument that it is time to stop cramming kids' heads with the Krebs cycle, Ohm's law, and the myriad other facts that constitute today's science curricula. Instead, what we need to teach is the ability to detect Bad Science--BS, if you will. The reason we do science in the first place is so that 'our own atomized experiences and prejudices' don't mislead us, as Ben Goldacre of the London School of Hygiene and Tropical Medicine puts it in his new book, Bad Science: Quacks, Hacks, and Big Pharma Flacks. Understanding what counts as evidence should therefore trump memorizing the structural formulas for alkanes.” ―Sharon Begley, Newsweek.com, on Bad Science
“Dr. Ben Goldacre's UK bestseller Bad Science: Quacks, Hacks, and Big Pharma Flacks is finally in print in the USA, and Americans are lucky to have it. Goldacre writes a terrific Guardian column analyzing (and debunking) popular science reporting, and has been a star in the effort to set the record straight on woowoo 'nutritionists,' doctors who claim that AIDS can be cured with vitamns, and vaccination/autism scares. Bad Science is more than just a debunking expose (though it's that): it's a toolkit for critical thinking, a primer on statistics and valid study design, a guide to meta-analysis and other tools for uncovering and understanding truth . . . The book should be required reading for everyone who cares about health, science, and public policy.” ―BoingBoing.net on Bad Science
Most helpful customer reviews
115 of 119 people found the following review helpful.
Another killer blow from the pen of Dr. Goldacre
By Guy Chapman
It is a common claim among alt med cranks that skeptics are only critical of alternative medicine. This is not and has never been true - most of Bad Science is about "Big Pharma" and its shenanigans, but this latest book by Ben Goldacre goes a lot further.
In "Bad Pharma" you will read about the ways in which vested interests bamboozle us and our doctors, whether by accident or design. You will find out why the benefits of most medicines are overstated, and why the systematic review is incredibly important. You will become, in short order, very angry indeed, and then you will be told what you can do about that anger - whether you are a patient or a doctor.
Goldacre's style is engaging and informal, and he is a practising doctor. The books include anecdotes about how he himself has unknowingly prescribed drugs which are not just ineffective, but worse than doing nothing - despite having read the research evidence with a particularly critical eye. All the data and references are there if you need them but they don't derail the narrative, so the book functions both as a reference and as an eminently readable story.
This is my pick for best book of the year so far, and one of the most important books most of us will have read. This is about your health. Get informed, get angry and get active!
68 of 69 people found the following review helpful.
The Upton Sinclair of Pharma....
By OSS architect
Dr Goldacre is an Epidemiologist, as am I. Or was. I changed fields because I saw examples, first hand, of what Dr Goldacre exposes in his book. Proper clinical trials are very difficult and expensive to do. You get obvious bad data in the raw observations, sample sizes are less than you want. Your power calculation on the sample size you have and the results you got suggest your P-value is bogus. You have to make judgements in some very grey areas. Every day.
You work with research MDs that won't have a career if they don't get results. As an Epidemiologist you work part time on numerous small grants that don't add up to an adequate salary, so many of us do (did) statistical work for drug company trials. You don't get recommended for further consulting work if you are "overly rigorous", shall we say.
In the late 70's new FDA requirements caused everyone to step up their game, but at increasing expense to doing trials. To contains costs, 30 years later, trials are now outsourced to about a half dozen separate specialist companies each doing one part of the study. A Clinical program management company, a data staging company, various companies that do the raw analysis (e.g. reading of CAT, MRI data), a company that prepares the results according to FDA submission requirements. All of them competing for the next contract, and competing on cost.
You can see where this is going....
I never witnessed any truly unethical behavior. There is no evil here. Personally, I chose to go into the software industry to avoid having to make daily ethical decisions. Dr. Goldacre wrote the book that many Epidemiologists could write. Hats off to him for actually doing it.
This ex-Epidemiologist only takes generic drugs, because the only good clinical trial is done on the general public, and after it comes off-patent, it's been around long enough to know it's efficacy and side effects.
52 of 53 people found the following review helpful.
A tough reality check on drug companies and legislation
By Martin Orsted
Bad Pharma highlights serious issues with the way the pharmaceutical industry works today. In the book Ben highlights the problems with the industry from several angles, how the tests can be tweaked, how negative tests are not published, how you can make a neutral test appear positive by sub-dividing the goals and then emphasize the fluke positive one. He also shows how the medical journals are part of the problem and the issue with ghost written articles. He shows the problems with the regulatory side as well, for example the European Medicines Agency, their lack of transparency, and how they have effectively blocked access to critical data for researchers. All through the book Ben makes use of well documented examples, and all the issues highlighted are well documented and exemplified.
The book is written in an easy to access language, and so it reads well. He does repeat himself a bit, so one more round of editing and cleanup before release would probably have been a good idea. Some readers on amazon.co.uk have criticised this, but I don't see it as an issue.
You don't need to have a degree in medicine or a higher degree in general to understand the issues Ben highlights.
Ben Goldacre runs the Bad Science website (badscience dot net) and has previously written the book Bad Science. Where Bad Science was an attack on quackery and pseudo science, and his website to a large degree has dealt with the same topics, this book is a critical look at the pharmaceutical industry. As such it ought to silence those that have attacked Ben Goldacre for being in the pockets of the Pharmaceutical industry over time.
Ben Goldacre has done society a big favour by writing this book. I definitely recommend reading it if you want to understand more about how US and European health care works and what can be done to improve it in the future.
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